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Updated: May 24, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Published on: November 28, 2019

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在结直肠癌中,协调的巨细胞和T细胞相互作用调解了对检查点阻塞的反应

Guillaume Mestrallet1, Matthew Brown1, Natalie Vaninov2

  • 1Division of Hematology and Oncology, Hess Center for Science & Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

bioRxiv : the preprint server for biology
|March 3, 2025
PubMed
概括

不匹配修复缺陷 (MMRd) 的结肠直肠癌 (CRC) 通常会抵抗抗PD-1疗法. 结合针对特定免疫细胞的免疫疗法,在MMRd CRC中消除了瘤,并在MMRp CRC中改善了反应.

关键词:
在 CTLA-4 中.在LAG3中.不匹配的修复缺陷的缺陷在PD-1中使用PD-1.在TREM2中,我们可以使用TREM2.免疫抵抗 免疫抵抗 免疫抵抗

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