尼古丁对血管和神经认知功能的影响与子宫内电子烟暴露
Amber Mills1,2, Deborah Corbin3, Duaa Dakhallah4
1Dept. of Physiology, Pharmacology & Toxicology, West Virginia University School of Medicine, Morgantown, WV 26506.
bioRxiv : the preprint server for biology
|March 3, 2025
概括
孕妇在怀孕期间使用电子烟 (Ecig) 会损害后代的脑血管功能,尼古丁会恶化神经认知缺陷并导致神经元损伤. 即使在低Ecig瓦的功率下,血管损伤也会发生.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 毒理学 毒理学 毒理学
背景情况:
- 在子宫内接触电子烟 (Ecigs) 可能会影响后代的脑血管和神经认知健康.
- Ecigs允许独立调查尼古丁和气溶毒性.
- 可变的Ecig功率设置可能会改变气溶的毒性.
研究的目的:
- 调查不同功率的母体Ecig暴露对后代脑血管和神经认知功能的长期影响.
- 为了确定观察到的效应是否独立于尼古丁.
主要方法:
- 时间配对的斯普雷格-道利大鼠从怀孕日2到21日暴露在埃吉斯身上.
- 后代 (男性和女性) 在1,3,6和12个月时被评估血管和神经认知功能.
- 测量了中脑动脉 (MCA) 的反应性.
主要成果:
- 在子宫内,Ecig暴露 (5w和30w) 损害了两性MCA反应能力,在更高的电源下更大的损害.
- 与尼古丁或没有尼古丁发生的血管功能障碍.
- 尼古丁暴露导致了老年后代的短期记忆缺陷,神经元损伤和神经炎症标志物.
结论:
- 母亲的电子烟会对后代的大脑健康产生不利影响,包括脑血管功能和神经认知.
- 在低暴露水平下,Ecigs的血管损伤可能会发生.
- 尼古丁会在子宫内暴露的后代中加剧神经认知和神经元损伤.
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