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使用纳米颗粒来克服非小细胞肺癌中抗PD-1/PD-L1免疫疗法抵抗:一种潜在的战略

Yuli Ge¹, Qiong Zhou², Fan Pan²

¹Department of Medical Oncology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People's Republic of China.

International journal of nanomedicine

|March 3, 2025

概括

纳米粒子可以在非小细胞肺癌 (NSCLC) 治疗中克服对免疫检查点抑制剂 (ICI) 的耐药性. 本综述探讨了耐药性机制以及纳米技术如何增强ICI治疗以获得更好的患者结果.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
纳米技术纳米技术

背景情况:

非小细胞肺癌 (NSCLC) 是全球癌症死亡的主要原因.
免疫检查点抑制剂 (ICI) 是有前途的,但面临的挑战是患者的反应变化和耐药性.
纳米粒子为增强瘤免疫治疗提供了独特的优势.

研究的目的:

审查NSCLC中对ICI耐药性的机制.
讨论纳米技术如何克服这些抵抗机制.
突出纳米颗粒作为改善NSCLCICI疗效的平台.

主要方法:

关于NSCLC,ICI和纳米粒子在癌症免疫治疗中的应用的文献综述.
对抗性机制的分析,包括抗原损失,T细胞功能障碍和免疫抑制瘤微环境 (TME).
对纳米粒子特性 (例如,EPR效应,主动准) 的探索,以增强ICI的潜力.

主要成果:

确定了NSCLC中ICI的关键抵抗机制:瘤抗原损失,抗原处理缺陷,T细胞反应受损和免疫抑制的TME.
纳米颗粒显示出增强药物输送,稳定性和调节TME的潜力.
特定的纳米粒子特性可以克服抗性并提高ICI的有效性.

结论:

纳米粒子是开发先进NSCLC免疫疗法的有希望的平台.
纳米技术的有针对性的应用可以帮助逆转ICI的阻力.
进一步研究基于纳米粒子的策略对于改善NSCLC治疗结果至关重要.

关键词:

在PD-1/PD-L1中.免疫抑制 TME 的免疫抑制.免疫疗法免疫疗法纳米颗粒是一种纳米粒子.有助于炎症的TME.阻力机制的阻力机制

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