艾滋病毒感染者CD4+T细胞计数与死亡风险之间的非线性关联:来自10年队列研究的证据

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Ruohan Sun^1,2, Huangchao Jia¹, Qiujia Kang^1,2

¹The First Affiliated Hospital of Henan University of CM, Zhengzhou, China.

Frontiers in medicine

|March 3, 2025

概括

较高的CD4+T细胞计数与艾滋病毒感染者 (PLHIV) 死亡风险较低有关. 低于350细胞/μL的CD4+T细胞计数是降低PLHIV死亡风险的关键值.

科学领域:

免疫学免疫学免疫学
流行病学流行病学
公共卫生公共卫生

背景情况:

了解CD4+T细胞计数和死亡率之间的关系对于管理HIV至关重要.
之前的研究已经探讨了这种关联,但特定于年龄的剂量-反应关系需要进一步研究.

研究的目的:

研究艾滋病毒感染者 (PLHIV) 中CD4+T细胞计数和死亡风险之间的剂量反应相关性.
确定与降低死亡风险相关的特定年龄的CD4+T细胞计数值.

主要方法:

对来自中国河南省4000名PLHIV患者的常规治疗数据的回顾性分析 (2003-2021年).
使用了卡普兰-梅尔分析,考克斯比例危险回归和受限立方线 (RCS) 模型.
参与者从30岁,40岁,50岁和60岁的年龄组中进行了选择.

主要成果:

在28158人年中,共有941人死亡,死亡率为每100人年3.34.
增加的CD4+T细胞计数与死亡风险比率 (HR) 的降低有关.
观察到一种非线性关联,死亡风险降低在CD4+T细胞计数215-382细胞/μL左右停滞,因年龄组而异.

结论:

在PLHIV中,CD4+T细胞计数和死亡风险之间存在非线性关系.
接近350细胞/μL的CD4+T细胞计数值对于减轻死亡率至关重要.
保持CD4+T细胞数量超过这一值是改善PLHIV生存的关键策略.

关键词:

CD4+ T 细胞计数 CD4+ T 细胞计数考克斯的比例危险回归模型.死亡风险,死亡风险.非线性协会非线性协会有限制的立方线.

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