相关实验视频

Updated: May 24, 2025

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Published on: July 15, 2020

非编码RNA和氧化应激在癌症进展中的交叉关系

Qiqi Sun¹, Xiaoyong Lei¹, Xiaoyan Yang¹

¹School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

Genes & diseases

|March 3, 2025

概括

癌症的进展与非编码RNA和氧化应激有关. 了解它们的相互作用可能会揭示癌症治疗的新疗法策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

全球癌症发病率上升,特别是在年轻人群中,与基因组不稳定性有关.
传统的癌症治疗因基因组不稳定性而面临挑战,突出了针对性治疗的需要.
非编码RNAs (ncRNAs) 在调节癌细胞生长和入侵方面发挥着关键作用.

研究的目的:

审查在癌症进展中将非编码RNA和氧化应激联系在一起的复杂机制.
探索氧化压力如何影响癌症基因表达和信号通路.
基于ncRNA-氧化应激相互作用来确定癌症治疗的潜在新疗法标.

主要方法:

文献综述侧重于ncRNAs与癌症中的氧化应激之间的相互作用.
分析控制ncRNA调节基因表达的分子机制.
检查反应性氧物种在癌症发展和进展中的作用.

主要成果:

非编码RNAs通过与信使RNA和蛋白质的相互作用来调节癌细胞的行为.
由自由基引起的氧化应激直接影响与癌症相关的基因表达和信号传递.
ncRNAs与氧化应激之间的相互作用是癌症进展的重要因素.

结论:

非编码RNA和氧化应激之间的相互作用是癌症进展的关键驱动因素.
针对这些分子途径为开发新型癌症疗法提供了有希望的途径.
对ncRNA-氧化应激机制的进一步研究可以导致更有效和更有针对性的癌症治疗.

关键词:

血管新生的产生.自自是一种自的过程.癌症癌症癌症癌症癌症能量代谢能量代谢表皮介质介质细胞转换.没有编码的RNAs.氧化应激是一种氧化应激.

更多相关视频

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

Production and Detection of Reactive Oxygen Species ROS in Cancers

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

相关概念视频

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

RNA Stability

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...