在细胞过程和疾病发病过程中LSD1的翻译后修改的多面性作用
Yinrui Li1,2, Bo Wang1,2, Yichao Zheng1,2
1State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality Control and Evaluation, Zhengzhou, Henan 450001, China.
Genes & diseases
|March 3, 2025
概括
翻译后修改 (PTMs) 调节蛋白质功能,其中LSD1 (lysine-specific demethylase 1) 在转录和疾病中发挥着关键作用. 它自己的PTM的影响活动,提供了对各种病理过程的见解.
科学领域:
- 生物化学和分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 翻译后修改 (PTM) 对蛋白质功能至关重要,已知有450多种类型影响着各种生物活动.
- 氨酸特异性去甲基酶1 (LSD1) 是一个关键的表观遗传调节剂,它从基因组H3K4和H3K9中去除甲基标记,以控制基因转录.
- 异常的LSD1表达与各种癌症和疾病有关,突显了其病理意义.
研究的目的:
- 审查LSD的结构特征和酶活性1.1.
- 总结LSD1.1.的已知和潜在的翻译后修改 (PTM).
- 阐明LSD1 PTMs在细胞过程中的作用及其与人类疾病的关联.
主要方法:
- 文献综述和对LSD1结构,功能和PTMs现有研究的综合.
- 对将LSD1失调和PTM与各种病理状况联系起来的研究进行分析.
- 收集有关影响LSD1活动和细胞作用的特定PTM的信息.
主要成果:
- LSD1的结构和特定的氨基酸残留对其脱甲基酶活性至关重要.
- LSD1经历了多种PTM,包括酸化,乙化,无化,甲基化,SUMOylation和S-nitrosylation,这些都调节了它的功能.
- LSD1及其PTMs的失调与癌症,代谢,神经,心血管和骨疾病有关.
结论:
- 了解LSD1的PTM提供了对其在生理和病理过程中的多面性作用的关键见解.
- LSD1 PTM及其功能之间的相互作用对正常细胞活动和疾病发展都很重要.
- 针对LSD1及其调节性PTM具有针对一系列人类疾病的治疗策略的潜力.
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