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Updated: May 24, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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用皮克林稳定抗泡封装布洛芬

Charalampos Tsekeridis1, Paloma Manuelle Marques da Silva1, Guilherme B Strapasson2

  • 1Niels Bohr Institute, University of Copenhagen, Copenhagen DK-2100, Denmark.

ACS omega
|March 3, 2025
PubMed
概括

这项研究表明,在Pickering抗泡中封装布洛芬可以改善味道和溶解度. 这种新的药物输送方法为增强的布洛芬配方和有针对性的输送提供了一个有希望的替代方案.

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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