聚合物 (聚乳-协同-甘油酸) 颗粒捕获 perfluorocarbons 是稳定的至少六年
Alvja Mali1, Navya U Nayak1, Jessie van Doesburg1
1Department of Cell Biology and Immunology, Wageningen University & Research, Wageningen 6708WD, The Netherlands.
ACS omega
|March 3, 2025
概括
装有高碳化合物的聚合物纳米粒子在-20°C下表现出超过六年的稳定性. 这一发现支持它们在长期临床应用中用于药物输送和体内成像.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 在药物输送中广泛使用的多 (乳酸-同-甘油酸) 纳米颗粒 (PLGA NPs).
- 将PLGA NP加载到完全碳化合物 (PFC) 中,可以通过19F NMR/MRI进行精确的体内成像和定量.
- 装有PFC的NP为定量体内细胞跟踪和可追踪药物输送提供了优势.
研究的目的:
- 开发和描述一个稳定的纳米配方用于临床转化.
- 在各种存储条件下评估充满 perfluorocarbon 的 PLGA 纳米粒子 (PLGA-PFCE NPs) 的长期稳定性.
- 为了确保临床应用的实际储存和处理.
主要方法:
- 使用单一油入水乳液方法合成PLGA-PFCENP.
- 在-20°C下长时间 (长达6年) 评估纳米粒子稳定性.
- 在冷解周期后,评估粉末和悬浮形式的NP稳定性.
- 在水和培养基中在4°C,室温和37°C下30天测试NP强度.
主要成果:
- 当PLGA-PFCE NP在-20°C保存时,其长期稳定性超过6年.
- 在经过多次冷解周期后,纳米粒子在粉末和悬浮形式都保持稳定.
- 在不同温度 (4°C,RT,37°C) 的水和培养基中,PLGA-PFCE NPs在长达30天的时间内表现出强度.
结论:
- PLGA-PFCE NP具有显著的长期稳定性,对于临床转化至关重要.
- 在各种条件下证明的稳定性促进了实际的临床处理和储存.
- 这些发现支持为先进的生物医学应用开发带有PFC的PLGANP.
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