在中国,患有精神分裂症第一发的年轻成年人中,认知能力的性别差异
NingJing Sang1, YiMin Fan1, HaiYing Chen1
1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, PR China.
Schizophrenia research. Cognition
|March 3, 2025
概括
与健康个体相比,精神分裂症患者表现出认知缺陷. 性别影响认知表现,精神分裂症女性在速度和口头学习方面表现优于男性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 精神分裂症的特点是影响日常运作的认知障碍.
- 人口因素,如性别影响精神分裂症的认知表现.
- 在第一发精神分裂症 (FES) 患者中神经认知功能障碍的性别差异尚未得到充分理解.
研究的目的:
- 为了比较FES患者和健康对照者 (HC) 之间的认知表现.
- 调查35岁以下中国人口认知表现的性别差异.
主要方法:
- 横截面研究设计. 截面研究设计.
- 使用MATRICS共识认知电池 (MCCB) 评估认知表现.
- FES患者和HC患者之间的比较,重点关注性别影响.
主要成果:
- 与HC相比,FES患者在所有MCCB领域表现出较低的认知功能.
- 患有FES的女性在处理速度和口头学习方面表现优于男性.
- 在HC中,男性表现出比女性更好的工作记忆和推理能力.
- 在FES和HC组中的女性在视觉学习方面表现出色.
- 多变量分析揭示了性别和诊断之间的相互作用对处理速度和口头学习的影响.
结论:
- 精神分裂症和生物性交互影响认知表现.
- 强调需要早期干预和针对精神分裂症认知缺陷的性别具体策略.
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