在先天免疫和多种疾病中,cGAS-STING通路无处不在的作用
Chunyan Deng1, Dongyan Chen1, Liang Yang2
1Department of Hematology and Oncology, Shenzhen Children 's Hospital, Shenzhen, China.
Frontiers in immunology
|March 3, 2025
概括
乌比基因化调节cGAS-STING通路,这是先天免疫的关键组成部分. 这个过程控制着对DNA的免疫反应,影响病毒防御和炎症,其失调与疾病有关.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- cGAS-STING通路是细胞质DNA的一个关键的先天免疫传感器.
- 它触发I型干扰素和炎症反应,对抗病毒防御和细胞应激至关重要.
- 随机化已经成为调节这种途径的关键翻译后修饰.
研究的目的:
- 检查在cGAS-STING通路中无处不在的调节作用.
- 了解无处不在如何影响cGAS和STING的稳定性,活性和降解.
- 探索cGAS-STING在先天性免疫和疾病中的含义.
主要方法:
- 审查和分析最近关于无处不在和cGAS-STING通路的研究.
- 在调节cGAS-STING信号传输中研究E3泛素酶在调节cGAS-STING信号传输中的作用.
- 检查了无处不在,NF-κB,IRF3/7,自和ER压力之间的相互作用.
主要成果:
- 乌比基因化动态控制cGAS和STING蛋白水平和信号传递.
- E3 泛基因酶是泛基因介导该途径调节的关键作用体.
- 不调节的cGAS-STING的无处不在与自身免疫性疾病,癌症和病毒感染有关.
结论:
- 乌比基化是cGAS-STING通路的关键调节者,对于维持免疫平衡至关重要.
- 针对无处不在的过程为与cGAS-STING功能障碍相关的疾病提供了潜在的治疗策略.
- 对特定的无处不在事件的进一步研究可以阐明精确的疾病机制.
相关概念视频
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
GPCRs Regulate Adenylyl Cylase Activity
5.1K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.1K
Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Caspases
11.8K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
11.8K
The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K
The Proteasome
793
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
793


