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Updated: May 24, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
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Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

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贝叶斯对多个实验忠实性的优化加速了药物分子的自动发现

Matthew A McDonald1,2, Brent A Koscher1, Richard B Canty1

  • 1Massachusetts Institute of Technology, Department of Chemical Engineering, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

ACS central science
|March 3, 2025
PubMed
概括

这项研究引入了多忠实贝叶斯优化 (MF-BO) 以通过高效利用不同成本和数据质量的实验来加速药物发现. 这种新方法成功地发现了具有改进性质的新型基因素脱乙酶抑制剂.

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