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在治疗结核病的耳毒药物治疗期间提供信息咨询:呼吁采取行动

K Khoza-Shangase¹, S M Arendse¹

¹Department of Audiology, School of Human and Community Development, University of the Witwatersrand, Johannesburg, South Africa.

Public health action

|March 3, 2025

概括

贝达奎林减少了对耐药结核病的耳毒药物的需求,但对一些广泛耐药结核病患者来说,氨基甘仍然至关重要. 早期的听力学咨询对于管理听力损失风险至关重要.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

贝达基林 (Bedaquiline,简称BDQ) 的引入已经减少了对抗药结核病 (DR-TB) 的氨基糖化物等耳毒药的依赖.
氨基糖化物对广泛耐药结核病 (XDR-TB) 病例至关重要,特别是对BDQ耐药的病例.
在南非,人们对氨基糖的耳毒性意识显著不足.

研究的目的:

突出阿米诺糖在XDR-TB治疗中的持续重要性.
强调需要提高对氨基糖化物诱导的耳毒性意识的必要性.
倡导为高危患者提供更好的信息和听力咨询服务.

主要方法:

在DR-TB和XDR-TB中对BDQ和氨基糖化物使用的文献综述.
分析南非的耳毒性患病率和意识.
审查当前的患者咨询实践.

主要成果:

虽然BDQ减少了耳毒性副作用,但对于某些XDR-TB患者来说,氨基糖化物是不可或缺的.
在南非,对氨基糖化物耳毒性的认识有限,这对南非构成重大风险.
抗药性结核病的增加需要改善患者教育和听力学支持.

结论:

听力学家必须在为需要氨基糖化物治疗的患者提供早期,结构化的咨询中发挥主动作用.
关于耳毒性风险的全面信息对于在DR-TB和XDR-TB中管理听力损失至关重要.
需要跨学科的合作,以减轻关键结核病药物的耳毒性作用.

关键词:

这就是DR-TB.南非南非南非在XDR-TB中使用XDR-TB.氨基甘油酸氨基化物.听力学听力学听力学贝达奎林贝达奎林是一种耳毒性耳毒性耳毒性结核病是一种肺结核病.

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