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前列腺特异性抗原密度和临床显著的前列腺癌:前列腺体积的影响

Elizabeth Robinson¹, Netty Kinsella², Derfel Ap Dafydd¹

¹Department of Radiology, Royal Marsden NHS Foundation Trust, London, UK.

|March 3, 2025

概括

前列腺特异性抗原密度 (PSAd) 检测临床显著前列腺癌 (csPCa) 的准确性因前列腺大小而异. 调整前列腺体积的PSAd值可以改善csPCa风险预测,并优化活检决策.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

前列腺特异性抗原密度 (PSAd) 是临床显著前列腺癌 (csPCa) 的关键预测因素.
关于前列腺体积如何影响PSAd的诊断性能的数据有限.
这项研究旨在评估不同前列腺体积的csPCa的PSAd准确性.

研究的目的:

为了确定PSAd在预测csPCa.的诊断准确度.
分析前列腺体积如何影响PSAd的敏感性和特异性.
评估 PSAd 值在不同前列腺大小的有用性.

主要方法:

追溯分析548名接受MRI和活检的患者.
患者分为小 (≤30毫升),中等 (>30至<50毫升) 和大 (≥50毫升) 前列腺体积组.
在csPCa的值≥0.10,≥0.15和≥0.20 ng/mL/mL时评估了PSAd的灵敏度和特异性.

主要成果:

在前列腺体积组中,PSAd诊断性能显著不同.
对csPCa的敏感性在小前列腺中最高,在大前列腺中最低.
特异性显示了相反的趋势,在小前列腺中最低,在大前列腺中最高.

结论:

单个PSAd值不足以准确预测所有前列腺体积的csPCa.
使用统一的PSAd值可能会导致前列腺较大的男性错过cspca诊断.
根据前列腺体积类别定制PSAd值可以提高csPCa的风险评估,并指导活检决策.

关键词:

PSA 密度 PSA 的密度腺癌瘤是一种腺癌.诊断的准确性诊断的准确性前列腺前列腺前列腺前列腺特异抗原前列腺特异抗原.前列腺的体积,前列腺的体积.

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