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Updated: May 24, 2025

Computer-Generated Animal Model Stimuli
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诱导多能干细胞中的SMAD2突变建模提供了对心血管疾病发病因子的洞察力

Tarsha Ward1, Sarah U Morton1,2, Gabriela Venturini1

  • 1Department of Genetics Harvard Medical School Boston MA USA.

Journal of the American Heart Association
|March 3, 2025
PubMed
概括

SMAD2变种破坏基因调节和染色质相互作用,这对心脏发育至关重要,解释了先天性心脏病 (CHD) 的变异. 了解这些分子效应有助于对不确定的SMAD2变体进行分类.

关键词:
基因编辑CRISPR/Cas9基因编辑这就是SMAD2的原因.遗传性心脏病是一种先天性心脏病.诱导多能干细胞的诱导干细胞.转录调节机制的转录调节机制.

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