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Updated: May 24, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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工程T7RNA聚合酶通过降低终端转移酶和RNA依赖RNA聚合酶活动来减少dsRNA的形成

Qiongwei Tang1, Sisi Zhu1, Nannan Hu2

  • 1Yeasen Biotechnology (Shanghai) Co., Ltd., China.

The FEBS journal
|March 3, 2025
PubMed
概括

研究人员设计了T7RNA聚合酶 (RNAP) 来减少双链RNA (dsRNA) 的副产品. 这种工程改善了蛋白质翻译并减轻了免疫应激,提高了体外转录应用的安全性.

关键词:
父亲们的父亲在T7RNA聚合酶中,指导进化是指导进化的.dsRNARNA 是一个在体外转录 in vitro转录

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