六角化纳米材料的生物降解由中性粒细胞
Zhuomiao Liu1,2, Jian Zhao1,3, Liyun Yin4
1Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao 266100, China.
Environmental science & technology
|March 3, 2025
概括
中性粒细胞降解六角化 (h-BN) 纳米材料,主要通过中性粒细胞外陷和髓氧化酶. 这种降解释放出有害的副产品,增加h-BN细胞毒性和血液溶解风险.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 毒理学 毒理学 毒理学
背景情况:
- 六角化 (h-BN) 纳米材料越来越多地用于各种应用.
- 了解h-BN的生物降解途径和生物影响对于评估其安全性至关重要.
- 中性粒细胞是关键的免疫细胞,参与清除外来物质.
研究的目的:
- 研究h-BN纳米材料由中性粒细胞的生物降解.
- 阐明参与h-BN降解的机制和途径.
- 评估h-BN降解产物的生物后果.
主要方法:
- 用中性粒细胞化h-BN纳米片.
- 高分辨率传输电子显微镜 (HR-TEM) 和共聚焦拉曼成像用于结构分析.
- 分子动力学模拟用于研究MPO-h-BN相互作用.
- 副产品的识别和第一原则的计算.
- 在上皮细胞上进行血解分析和细胞毒性测试.
主要成果:
- 中性粒细胞在36小时内吸收并显著破坏h-BN纳米片.
- 中性细胞细胞外陷 (NETs) 和髓氧化酶 (MPO) 是h-BN降解的核心.
- MPO利用低化物形成B-O和N-O键,破坏B-N键并释放离子和.
- 降解使小h-BN颗粒 (0-100 nm) 的度增加了58.7%.
- 降解的h-BN诱导显著的红细胞血解,并增加对上皮细胞的细胞毒性.
结论:
- 通过中性粒细胞介导的h-BN降解是一个重要的生物过程.
- 降解途径涉及MPO,并导致细胞毒性副产品.
- 这些发现强调了考虑安全应用的h-BN降解的重要性.
- 在生物和自然环境中,与h-BN相关的实际风险存在.
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