生物启发的长效粘膜粘合性胃贴片用于输送莱沃甲状腺素
Srivarsha Reddy Bollareddy1, Shreya Shashank Chauhan1, Venkata Vamsi Krishna Venuganti1
1Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, Telangana, India.
ACS applied materials & interfaces
|March 3, 2025
概括
一种新型的生物灵感粘粘性胃贴片使得长效的甲氧 (LT) 可以通过口服输送. 这种药物输送系统在没有显著炎症反应的老鼠中维持了38天的治疗性LT水平.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 胃肠病学 胃肠病学
背景情况:
- 长效治疗剂型的口服输送存在重大挑战.
- 利沃胺 (LT) 需要精确和一致的剂量才能有效治疗.
- 现有的输送方法可能无法确保持续的治疗水平.
研究的目的:
- 开发和评估一种生物灵感的粘粘性胃贴片,用于长效的甲氧 (LT) 口服.
- 在大鼠模型中评估LT装载粘膜贴片的粘附性,稳定性和体内性能.
主要方法:
- 一个三层粘膜贴片 (核心,粘膜贴片,背面) 是使用4 - 碳氧乙酸 - 基托桑结合物制造的.
- 测量了水接触角度和对大鼠胃粘膜的粘合强度.
- 带有LT的贴片被口服给大鼠,并在38天内监测血LT度和炎症标志物.
主要成果:
- 粘膜层的水接触角度为68±1.4°,粘合强度为25±1.1kPa.
- 贴片在老鼠的胃上坚持超过30天.
- 一次剂量可维持38天的LT血度 (87-126 ng/mL),但炎症标志物 (TNF-α,IL-1β,IL-6) 没有显著增加.
- 贴片在5±3°C保存6个月后显示稳定性.
结论:
- 生物启发的粘粘性胃补丁是一种有希望的平台,可持续口服输送利沃氨酸.
- 开发的系统为改善长期治疗疗效和患者遵守提供了潜在的解决方案.
- 进一步的研究可能会探索其适用于其他需要长期作用的口服药物的应用.
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