在口服多微生物生物膜控制上对莫林和卡瓦克罗尔装载纳米颗粒的评估
Luciana Solera Sales1, Amanda Letícia Polli Silvestre2, Marlus Chorilli2
1Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Biofouling
|March 3, 2025
概括
甲基酸盐/奇托桑纳米颗粒有效地对抗口腔生物膜. 添加莫林或卡瓦克罗尔可以增强它们的抗菌和抗菌膜特性,为口腔健康提供了一个有前途的策略.
科学领域:
- 生物材料科学 生物材料科学
- 微生物学 微生物学
- 纳米技术纳米技术
背景情况:
- 口腔生物膜是复杂的微生物群落,对各种口腔疾病负责.
- 需要使用抗微生物策略来有效管理和预防口腔生物膜的形成.
- 酸盐和酸盐是适合纳米粒子开发的生物相容聚合物.
研究的目的:
- 开发和表征甲基酸盐/酸盐纳米颗粒 (NP).
- 评估这些NP的抗菌和抗菌膜活性,有或没有莫林或卡瓦克罗尔,与口服生物膜相比.
- 评估这些NP作为口腔治疗策略的潜力.
主要方法:
- 合成和表征的奇托 (CS):酸 (SA) 纳米粒子 (NP) 与不同的CS:SA比率 (0.15:1至0.5:1).
- 将天然化合物莫林或卡瓦克罗尔纳入NP.
- 评估NP属性 (大小,泽塔潜力,SEM,封装效率,药物释放) 以及它们对多微生物口服生物膜 (生物质,可活微生物,酸性) 的抗微生物/抗生物膜疗效.
主要成果:
- 开发的NP表现出纳米尺寸 (<500nm),球形和光滑表面.
- 摩林的封装效率在46.17-55.15%之间,而卡瓦克罗尔的封装效率在55.30-90.15%之间.
- NPs显著降低了口腔生物膜生物质和微生物活力,在添加莫林或卡瓦克罗尔时效果得到增强. 药物完全释放发生在15分钟内.
结论:
- 酸基酸盐纳米颗粒有效抑制口腔生物膜的形成,并降低微生物的活力.
- 添加天然化合物莫林或卡瓦克罗尔显著增强了抗微生物和抗菌膜的作用.
- 这些复合纳米粒子代表了口服应用的有希望的策略,用于对抗生物膜依赖性疾病.
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