睡眠碎片化,24小时休息活动模式,以及在亨廷顿氏病前表现的认知功能:一个动图学研究
Emily S Fitzgerald1, Yifat Glikmann-Johnston1, Jessica E Manousakis1
1Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University.
Neuropsychology
|March 3, 2025
概括
睡眠碎片化和休息活动模式的破坏与先发性亨廷顿病 (Pre-HD) 的认知衰退有关. 保持不间断的睡眠对于保持患HD风险的人的认知功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 认知科学 认知科学
背景情况:
- 亨廷顿病 (HD) 是一种神经退行性疾病.
- 在诊断前多年,HD前患者会经历认知症状,睡眠障碍和活动模式的改变.
- 睡眠/活动模式和在HD前的认知之间的关系还不太清楚.
研究的目的:
- 调查休息活动模式,睡眠质量和在HD前的认知表现之间的关联.
- 为了比较Pre-HD个体和健康对照 (HCs) 之间的这些模式.
主要方法:
- 用于睡眠和活动监测的14天动态图.
- 睡眠质量和失眠评估的在线问卷.
- 远程认知评估包括处理速度,记忆和执行功能的测试.
主要成果:
- 与HC相比,HD前的参与者在快速点击方面表现较差.
- 在PRE-HD中增加睡眠碎片化与Trail Making Test (TMT) 和霍普金斯口语学习测试修订 (HVLT-R) 的表现更差相关.
- 更稳定,更少碎片化的休息活动模式 (更高的日间稳定性) 与多个认知测试的表现较差有关,包括TMT Part B和HVLT-R.
结论:
- 不间断的睡眠对于前HD患者的认知功能至关重要.
- 睡眠和活动模式代表了干预措施的潜在目标,以减轻HD前的认知症状.
- 需要对更大,分层的队列进行进一步的研究,以充分理解在预先显现的HD频谱中的这些关系.
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