在非小细胞肺癌的分子和临床背景下,三级淋巴体结构的空间分布
Hedvig Elfving1, Hui Yu2, Kaleab Kassete Fessehatsion2
1Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, 751 85, Sweden. hedvig.elfving@igp.uu.se.
Cellular oncology (Dordrecht, Netherlands)
|March 3, 2025
概括
三级淋巴状结构 (TLS) 在非小细胞肺癌 (NSCLC) 中很常见,并且与更好的生存率有关. 它们的存在,特别是在瘤外围,表明了相关的免疫反应,并有助于预测患者的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 是淋巴细胞聚合物,对癌症免疫至关重要.
- 对TLS的模两可的形态定义阻碍了对其对患者生存和免疫治疗反应的临床影响的评估.
研究的目的:
- 在肺癌组织段中对TLS进行表征.
- 评估与免疫微环境,突变格局和NSCLC患者结果相关的TLS发生情况.
主要方法:
- 病理学家对680个NSCLC切除标本的评估.
- 在瘤周边和区域内对TLS (成熟/未成熟) 的空间量化和分类.
- 整合TLS指标与免疫细胞计数,基因组/转录组数据和临床参数.
主要成果:
- 在86%的病例中检测到TLS,主要是外围的.
- 在24%的病例中观察到成熟的TLS.
- TLS的存在与血细胞和淋巴细胞透 (CD3 +,CD8 +,FOXP3 +) 的增加相关.
- 较高的瘤突变负担与增加的外围TLS有关.
- 总体TLS数量独立地与改善的生存率相关;外围TLS显示出预后意义.
结论:
- TLS在NSCLC中普遍存在,并且与独特的免疫表型相关,这表明生物相关性.
- 在常规的H&E部分进行TLS评分可能会增强NSCLC诊断算法和预后评估.
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