纳洛知识,携带,购买和使用
Mireille Jacobson1, David Powell2
1University of Southern California, Los Angeles.
JAMA network open
|March 3, 2025
概括
大多数阿片类药物依赖的人都知道和携带纳洛,通常没有购买它. 这凸显了需要创新的方法,如在线调查,以有效地追踪纳洛持有.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 广泛获得纳洛对于解决阿片类药物危机至关重要.
- 估计纳洛的可用性往往依赖于药房销售,不包括其他分销道.
研究的目的:
- 为了评估美国成年人的纳洛知识,携带行为,购买历史和管理.
- 了解纳洛在全国样本中的使用情况以及阿片类药物依赖的个体.
主要方法:
- 一项跨部门在线调查于2024年6月7日至29日进行.
- 包括来自全国样本和自报阿片类药物依赖样本的18岁以上非机构成年人.
- 评估了纳洛的知识,携带,购买和使用,暴露包括阿片类药物滥用和过量使用风险.
主要成果:
- 高比例的阿片类药物依赖者 (89.0%) 知道纳洛的用途,60.5%携带它,而全国样本中的比例分别为46.2%和10.6%.
- 在高危过量或认识高危人群中,阿片类药物依赖组 (73.8%和70.1%) 的携带率明显高于全国样本 (31.0%和25.4%).
- 大多数携带的纳洛不是购买的;在阿片类药物依赖者中,使用率更高 (47.5%使用, 39.3%接受).
结论:
- 患有阿片类药物依赖的个人表现出高度的意识和纳洛的携带,通常通过非购买道获得.
- 研究结果表明,目前的方法可能低估了纳洛的可用性和持有率.
- 快速在线调查提供了一种可行的方法来监测纳洛持有情况,并为公共卫生战略提供信息.
相关概念视频
Opioid Receptors: Overview
422
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
422
Opioid Analgesics: Synthetic and Semisynthetic Opioids
204
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
204
Opioid Analgesics: Morphine and Other Natural Cogeners
160
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
160
Analgesia and Pain Management
422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
Drug Delivery: Enteral Route
365
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
365
Prevention of Further Absorption of Poison
777
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
777


