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Clara M Bögerl¹, Frederik B Laun¹, Armin M Nagel¹

¹Institute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

|March 3, 2025

概括

临床MRI研究显示,样本大小的变化很大. 患者人数中位数为74.5,大多数研究使用的患者人数少于350人,突出需要仔细选择样本大小.

科学领域:

放射学放射学是一门学科.
医疗成像医学成像
临床研究临床研究

背景情况:

在临床MRI研究中确定适当的样本大小是复杂的,因为参数的可变性.
之前的研究为新的临床MRI研究中的样本大小选择提供了参考.
对当前实践的系统调查有助于确定样本大小.

研究的目的:

系统地调查临床MRI研究中的样本大小.
根据当前的做法,为选择样本大小提供指导.
分析已发表的临床MRI研究中的样本大小趋势.

主要方法:

在2020-2023年期间评估了1046篇来自"磁共振成像杂志" (JMRI) 的文章.
仅包括基于患者的临床MRI研究,不包括评论,幻影,动物和非成像技术.
根据解剖区域,场强度,对比度类型,研究设计和评估方法对研究进行分类.

主要成果:

在734项研究中,平均样本大小为74.5名患者.
追溯研究的中位数为129名患者,而前性研究的中位数为41.
样本大小通常以十的倍数聚集; 90.3%的研究使用了<350名患者.

结论:

临床MRI研究的样本大小因研究类型,内容和方法学而异.
在临床MRI中,平衡统计能力与尽量减少患者数量至关重要.
仔细的样本大小选择对于有效的临床MRI研究设计至关重要.

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