基于联合知识网络的可解释性肝癌分期预测
IEEE journal of biomedical and health informatics
|March 3, 2025
概括
通过使用放射学报告中的隐性知识,KnowST改善了肝癌的分期. 这种可解释的AI模型提高了准确性,并帮助肝细胞癌 (HCC) 患者的临床决策.
科学领域:
- 医疗信息学 医疗信息学
- 人工智能在医学中的应用
- 放射学报告 放射学报告
背景情况:
- 肝细胞癌 (HCC) 的准确临床分期对于治疗和生存至关重要.
- 目前的分期方法在区分类似的文本特征方面面临挑战,缺乏可解释性.
研究的目的:
- 推出KnowST,一个联合知识网络,用于解释性预测肝癌的病期.
- 为了提高分期准确度,利用放射学报告中的隐性知识.
主要方法:
- 开发了一个联合知识网络 (KnowST),专注于与阶段相关的隐性知识.
- 利用了"阶段到阶段"和"因素到阶段"的相关性视角.
- 在中国放射学报告中包含域特定的词嵌入.
- 综合瘤因子预测,提高模型的可信性和可解释性.
主要成果:
- 在573份真实世界放射学报告中,KnowST实现了90.52%的准确性.
- 与最佳基线相比,曲线下的面积 (AUC) 提高了7.69%.
- 在多个指标上表现出卓越的阶段识别和稳定的性能.
结论:
- KnowST有效地利用放射学报告中的隐性信息来进行可解释的临床分期.
- 该模型提高了深度学习在分阶段预测中的可信度和可解释性.
- KnowST提供了一种有前途的方法,可以改善肝细胞癌的分期和患者的治疗结果.
相关概念视频
Cancer Survival Analysis
319
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
319
End Point Prediction: Gran Plot
234
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
For potentiometric titration, the Gran plot is created by plotting...
234
Gross Anatomy of the Liver
266
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
266
Hepatic Portal System
848
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
848


