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光学驱动的数字视网膜假体架构的可行性评估,用于视网膜腺细胞刺激

William Lemaire, Maher Benhouria, Konin Koua

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

|March 3, 2025

概括

这项研究介绍了一种新的无线视网膜植入系统,该系统使用近红外光来提供电力和数据,克服了以前有线植入器的局限性. 该系统成功地引起了盲人视网膜的神经反应,为改进视觉假肢铺平了道路.

科学领域:

生物医学工程生物医学工程
神经科学是一个神经科学.
眼科医生眼科眼科

背景情况:

视网膜神经元的电刺激可以引起盲人患者的视觉感知.
现有的视网膜植入物具有有限的视觉敏度和由于穿皮电缆的手术并发症.

研究的目的:

引入一种由近红外 (NIR) 光驱动和控制的新型无线视网膜植入物架构.
克服有线植入物的局限性,例如可靠性降低和手术风险降低.

主要方法:

使用多连接光伏电池和CMOS刺激器与钻石微电极阵列开发了一种视网膜植入物.
用于电力和数据传输的NIR照明 (850nm在4mW/mm2) 使用.
在一只退化的老鼠视网膜中使用光成像与指示器证明了神经反应的诱导.

主要成果:

这种由NIR驱动的系统成功地为刺激器提供动力,并在视网膜质细胞 (RGCs) 中引起反应.
在平均刺激值时达到高刺激率,高达每秒35,000次脉冲.
证实了对RGCs无线高重复率刺激的可行性.

结论:

呈现的红外驱动的数字视网膜植入体架构可用于引起神经反应.
这种无线方法为更可靠,更少侵入性视觉假肢提供了潜在的解决方案.
需要进一步的研究来解决局限性,并优化视力敏度恢复.

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