在1年固定剂量aflibercept治疗后实现不活跃的多重型冠状血管病变后,复发的多重型病变
Voraporn Chaikitmongkol1, Wantip Tadadoltip2, Direk Patikulsila1
1Retina Division, Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
概括
近一半的多性冠状血管病变 (PCV) 患者经历了aflibercept治疗后的复发. 不完整的息肉回归和特定的OCT发现预测复发,建议对高风险的眼睛进行更密切的监测.
科学领域:
- 眼科医生 眼科 眼科
- 医疗视网膜 医学视网膜
- 冠状血管病变 - 冠状血管病变
背景情况:
- 聚冠状血管病变 (PCV) 是视力丧失的常见原因.
- 在初始治疗后,PCV的复发很频繁,但时间并不清楚.
- 阿弗利伯塞普是PCV的标准治疗方法,通常涉及初始固定的剂量,然后按需要 (PRN) 管理.
研究的目的:
- 为了研究一年固定剂量aflibercept治疗后,在未经治疗的PCV眼睛中首次发生多性复发的时间.
- 为了确定与PCV患者多性复发相关的风险因素.
主要方法:
- 对以前没有接受过治疗的PCV眼睛进行了回顾性队列研究.
- 患者在第一年接受固定剂量2mg的aflibercept.
- 在第一年达到不活动的眼睛 (在OCT上没有网膜内/网膜下液体) 在治疗后的第一年 (PTY1) 进行了至少12个月的跟踪.
- 复发被定义为OCT上液体的存在;风险因素使用 fundus 摄影,ICGA 和OCT进行了评估.
主要成果:
- 在37只眼睛中,18只 (49%) 的眼睛出现了复发.
- 在18个眼睛中,14个眼睛 (78%) 在PTY1后12个月内出现复发.
- 在治疗后ICGA (HR=4.4) 和在OCT (HR=2.7) 上具有异质反射性的PED上的不完整的多回归是复发的重要风险因素.
结论:
- 在接受一年固定剂量阿弗利塞普特治疗的PCV眼睛中,近一半的患者出现了复发.
- 某些高风险特征,只能通过OCT检测到,预测复发.
- 建议对PCV患者进行密切监测,鉴定出具有复发高风险特征的患者.
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