塞夫塔齐迪姆-阿维巴克坦与特定的静脉注射抗微生物药物的物理兼容性在模拟的Y位处方中
Fangyuan Chen1,2, Haiwen Ding1, Sheng Liu1
1Pharmacy, The First Affiliated Hospital of USTC, Hefei, Anhui, China.
概括
在Y位处方期间,Ceftazidime-avibactam与七种常见的静脉注射抗微生物药物在物理上兼容. 这一发现支持在临床环境中同时使用,确保安全有效的患者治疗.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 临床药房 临床药房
- 传染性疾病 传染性疾病
背景情况:
- 塞法胺-阿维巴克坦是治疗多抗药性格拉姆阴性感染的关键抗生素.
- 在临床实践中,通过Y位点同时注射静脉药物是常见的.
- 评估身体相容性对于预防与药物相关的并发症至关重要.
研究的目的:
- 为了评估ceftazidime-avibactam与选择的静脉注射抗微生物药物的物理兼容性.
- 通过Y站点确定与其他常用抗生素同时使用塞夫塔齐迪姆-阿维巴克坦的安全性.
主要方法:
- 塞法胺-阿维巴克坦被混合与tigecycline,美特罗尼达,梅罗,伊米佩内姆-cilastatin,斯福米辛,阿兹特雷诺姆和万科米辛.
- 混合物在0,1,2和4小时后进行视觉变化,Tyndall光束,度,pH,光谱吸收和粒子计数的评估.
- 在室温下使用模拟的Y位处方条件.
主要成果:
- 在任何一个Ceftazidime-avibactam添加剂中都没有观察到不相容的视觉迹象.
- 度,泰达尔光束,pH值,光谱吸收和粒子计数在所有组合中都保持在可接受的范围内.
- 所有测试的添加剂在整个4小时的观察期间都显示出物理兼容性.
结论:
- 塞法胺-阿维巴克坦与tigecycline,metronidazole,meropenem, imipenem-cilastatin,phosfomycin,aztreonam和vancomycin在物理上是兼容的.
- 这些发现表明,ceftazidime-avibactam可以安全地与这些抗微生物药物通过Y位点输液同时使用.
- 这种兼容性支持在临床环境中灵活和高效的治疗方案.
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