氧化应激在COVID-19后急性后果中的参与:临床影响
Paola Mayara Valente Coronel1, Denise Caroline Luiz Soares Basilio1, Isabelly Teixeira Espinoça1
1Faculdade de Ciências Farmacêuticas Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Redox report : communications in free radical research
|March 3, 2025
概括
COVID-19 (PASC) 后急性后果与增加的氧化应激 (OS) 和炎症有关. 监测OS生物标志物可能有助于管理PASC并发症.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 氧化应激 (OS) 与COVID-19的发病和长期影响有关.
- COVID-19 (PASC) 后急性后续可能涉及持续的OS和炎症.
研究的目的:
- 评估PASC患者的OS和炎症生物标志物.
- 为了比较健康个体,急性COVID-19患者和PASC患者之间的生物标志物水平.
主要方法:
- 血液样本分析了炎症性细胞因子 (IL-6,IL-8),骨髓氧化酶 (MPO) 和OS标记物 (SOD,CAT,GST,GGT,GSH,UA,TBARS,PC).
- 参与者群体:健康 (n=20),急性COVID-19 (n=15),PASC (n=29). 参与者群体:健康 (n=20),急性COVID-19 (n=15),PASC (n=29) 参与者群体:健康 (n=20),急性COVID-19 (n=15) 参与者群.
主要成果:
- 在PASC组中,IL-6,IL-8,GGT,GSH,尿酸 (UA) 和蛋白质碳基 (PC) 的含量增加.
- 这两组COVID-19患者的超氧化脱酶 (SOD) 和酶 (CAT) 含量都降低了.
- 在PASC患者中观察到炎症和OS标志物之间的相关性.
结论:
- 患有PASC的个体表现出显著的氧化应激,可能会恶化疾病并发症.
- 监测OS生物标志物可能有助于PASC预后和患者管理.
关键词:
这就是SARS-CoV-2病毒.抗氧化剂 抗氧化剂是一种抗氧化剂.慢性COVID综合征是一种疾病.细胞因子 细胞因子这是一种炎症炎症炎症炎症.长时间的COVID.氧化应激是一种氧化应激.有活性氧物种的反应性氧物种.更多相关视频
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