在核中A2A阳性神经元Accumbens核心调节努力的运动
Charles T Shoemaker1, Alexander D Friedman1, Bryan Lu1
1Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708.
概括
核心 accumbens 间接途径双向调节努力. 激活这些神经元会减少努力,而抑制它们会增加努力,为动机和奖励处理提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 奖励系统奖励系统
背景情况:
- 核心 accumbens (NAc) 参与调节基于努力的决策.
- 在NAc中的特定神经元群体及其在努力调节中的作用仍然不明.
研究的目的:
- 调查直接途径脊柱投射神经元 (dSPN) 和间接途径脊柱投射神经元 (iSPN) 在NAc核心中在努力调节中的不同作用.
- 为了确定NAc核心神经元活动是否可以双向控制劳动力.
主要方法:
- 在雄性和雌性小鼠中利用了一个操作性劳动力调节任务.
- 使用光遗传学来操纵NAc核心中的dSPNs (D1+) 和iSPNs (A2A+) 的活性.
- 测量杆按压作为劳动力的指标.
主要成果:
- 激活NAc核心dSPNs可以通过诱导像咬这样的竞争行为来减少杆压力,而不依赖于努力水平.
- 激活NAc核心iSPNs以依赖力度的方式减少了杆按压,在更高的力度要求下降更大.
- 抑制NAc核心的iSPN输出导致了增加的努力.
结论:
- 来自NAc核心的间接路径输出在努力调节中起着至关重要的作用.
- NAc 核心 iSPN 活动可以双向控制为获得奖励所付出的努力量.
相关概念视频
Regulation of Food Intake
174
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
174
Sympathetic Signaling
828
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
828
Physiology of Respiration II: Neurogenic Control of Respiration
438
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
438
Physiological Control of Respiration
1.8K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
1.8K
Brainstem: Control Centers of Medulla
1.4K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
1.4K
Neural Control of Respiration
2.0K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
2.0K


