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Updated: May 24, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Published on: February 7, 2019

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异素尿素催化酶选择性松-异环合成通过自我纠正的胺和烯酸乙烯酸结合启用

Martha I Prindl1, Matthew T Westwood1, Alister S Goodfellow1

  • 1EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, UK.

Angewandte Chemie (International ed. in English)
|March 3, 2025
PubMed
概括

这项研究引入了一种新型的催化方法,用于合成具有高反选择性的化pyrazolo-heterocycles. 该过程利用异氨基酸催化剂进行高效的迈克尔添加-循环反应,为药物和农业化学应用创造有价值的化合物.

关键词:
选择性的迈克尔加法.异二烯氨酸是一种异二烯氨酸.皮拉 (Pyrazole) 是一种可怕的药物.自行纠正的胺基乙化.

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