患有MIS-C的儿童冠状动脉扩张:患病率,危险因素和进展情况
Phung Nguyen The Nguyen1,2, Tran Thanh Thuc3,4, Nguyen Thanh Hung2,5
1University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
European journal of pediatrics
|March 3, 2025
概括
患有多系统炎症综合征 (MIS-C) 的儿童的冠状动脉扩张通常在三个月内消失. 男性性别, kawasaki-like症状和中腔淋巴炎是MIS-C患者这种心脏并发症的关键风险因素.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 是SARS-CoV-2感染后的一种严重疾病.
- 心脏并发症,特别是冠状动脉扩张,是MIS-C的一个主要问题.
- 了解风险因素和恢复对于管理MIS-C患者至关重要.
研究的目的:
- 为了确定冠状动脉异常在越南儿童MIS-C.的患病率.
- 确定与MIS-C.冠状动脉扩张相关的风险因素.
- 在3个月的随访期内评估冠状动脉异常的进展和恢复.
主要方法:
- 在越南进行了一项前性的多中心病例系列研究.
- 根据世卫组织的标准诊断出195名MIS-C患者,并在出院后进行了3个月的随访.
- 收集和分析了人口统计,临床特征,实验室发现和治疗方法的数据.
主要成果:
- 33.3%的MIS-C患者在入院时出现冠状动脉异常.
- 冠状动脉扩张的独立风险因素包括男性性别, kawasaki-like表型和中腔淋巴腺炎.
- 3个月后,只有3.6%的患者出现了持续的冠状动脉异常,这表明了有利的恢复.
结论:
- 在MIS-C患者的冠状动脉扩张显示了在三个月内积极的恢复趋势.
- 男性性别, kawasaki-like MIS-C 和中腔淋巴腺炎是发展冠状动脉扩张的重要独立危险因素.
- 早期识别这些风险因素可以帮助及时干预和管理MIS-C心脏并发症.
更多相关视频
13:10Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
Published on: April 24, 2017
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
相关概念视频
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:30Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
01:27Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...