相关实验视频

Updated: May 24, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

双S对小鼠早期胚胎发育的有害影响

Christina Mantzouki¹, Despoina Mavrogianni², Maria Papagianni³

¹Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion Hospital, Athens Medical School, National and Kapodistrian University of Athens, 76 Vas. Sofias Str., Athens, 10674, Greece.

Hormones (Athens, Greece)

|March 3, 2025

概括

双S (BPS) 暴露显著降低了早期小鼠胚胎存活率,即使在低剂量. 这些发现表明BPS对胚胎发育的潜在风险,需要进一步研究.

科学领域:

生殖毒理学生殖毒理学
发展生物学发展生物学
环境健康环境健康

背景情况:

西方国家不孕率不断上升,促使人们对内分泌干扰物的研究.
双A (BPA) 是一种已知的内分泌干扰物,导致其在某些地区被禁止.
双S (BPS) 是BPA的结构模拟物,越来越多地用作替代品.

研究的目的:

为了研究双S (BPS) 对小鼠胚胎早期发育的影响.
为了确定不同BPS度对胚胎存活率的影响.

主要方法:

CD1小鼠胚胎在体外培养时具有不同度的BPS.
每天监测胚胎存活率,并与对照组进行比较.
测试的BPS度包括1,10和100 pg/ml.

主要成果:

在所有测试的BPS剂量 (1, 10, 100 pg/ml) 中观察到胚胎存活率显著下降.
BPS对生存的不良影响从暴露的第一天就显而易见,即使是最低剂量 (1 pg/ml).

结论:

这项研究是首次报告BPS对小鼠胚胎存活的影响.
BPS对小鼠胚胎早期发育产生潜在的不良影响,影响生存率.
暴露于BPS的剂量,时间和持续时间极大地影响了胚胎的存活率,引发了对人类胚胎的安全担忧.

关键词:

双 S 是一种双醇.胚胎发育的发展胚胎是如何形成的内分泌干扰物干扰内分泌干扰物女性的生殖系统是女性的生殖系统.

更多相关视频

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...