整合生物信息学和代谢学,以确定高血压性病的潜在生物标志物
Kezhen Yang1, Pingna Zhang2, Xiaofeng Ding3
1Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, Zhejiang, China. 767299632@qq.com.
Scientific reports
|March 3, 2025
概括
高血压性脏病 (HN) 涉及不清楚的途径. 这项研究确定了关键基因 (APOE,ALB,SERPINA1) 和胆酸 (CA,DCA,TDCA),与早期HN进展和高血压有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
- 基因组学就是基因组学.
背景情况:
- 高血压脏病 (HN) 是末期脏疾病的主要原因,但其致病性仍然不清楚.
- 了解涉及HN进展的生物学途径和生物标志物对于早期诊断和治疗至关重要.
研究的目的:
- 确定涉及高血压脏病 (HN) 进展的生物途径.
- 为了发现HN的胆汁酸 (BA) 相关生物标志物.
- 阐明胆酸在HN发展中的作用.
主要方法:
- 下载并分析基因微阵列数据,以识别HN中差异表达基因 (DEGs).
- 在DEGs上进行了基因本体学和基因和基因组丰富分析的京都百科全书.
- 构建了一个蛋白质-蛋白质相互作用 (PPI) 网络,并集成BA目标以识别枢纽基因.
- 建立了早期高血压脏病动物模型 (SHR) 并量化了皮层中的39种胆酸.
主要成果:
- 确定了398个DEG和与高血压和病相关的多个生物学途径.
- 发现了三个BA相关的枢纽基因:APOE,ALB和SERPINA1.
- 在早期HN中发现了七种胆酸 (DCA,CDCA,UDCA,UCA,CA,TDCA,TCDCA) 的显著度差异.
- 在SHR模型中观察到特定胆汁酸 (CA,DCA,TDCA) 和血压之间的正相关性,表明诊断潜力.
结论:
- 已确定的枢纽基因 (APOE,ALB,SERPINA1) 和高胆酸,特别是CA,DCA和TDCA,可能与高血压脏病 (HN) 的早期阶段有关.
- 这些与BA相关的生物标志物与血压具有显著的相关性和特异性,这表明早期HN检测的诊断价值很高.
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