血清25-基维生素D度与美国COPD成年人群肺功能之间的非线性相关性
Zhongqiu Han1, Jie Yang1, Yiming Du1
1Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, No. 16766 Jingshi Road, Jinan, 250000, People's Republic of China.
Scientific reports
|March 3, 2025
概括
低维生素D水平与COPD患者的肺功能恶化有关. 随着维生素D (25-氧维生素D) 水平降至90nmol/L以下,肺功能下降,但在这个值以上稳定.
科学领域:
- 肺部医学 肺部医学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 维生素D在COPD中的作用受到争议,其对肺功能影响的证据相互矛盾.
- 之前的研究表明潜在的保护作用,但明确的关联仍然难以捉摸.
研究的目的:
- 为了研究血清25-基维生素D (25-OHD) 水平与COPD社区居民的肺功能之间的相关性.
- 为了确定维生素D状态与空气流阻塞的严重程度之间的特定关系.
主要方法:
- 利用来自1384名COPD患者的国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,分层分析,限制立方线 (RCS) 和值效应分析.
主要成果:
- 在血清25-OHD度和肺功能之间观察到一个反向的L形关系.
- 肺功能下降,25-OHD水平降至90nmol/L以下.
- 在25-OHD水平和90nmol/L或以上的肺功能之间没有发现显著的关联.
结论:
- 血清25-OHD度显示,在美国的COPD成年人中,与气流阻塞严重性的反向L形关联.
- 存在值效应,肺功能下降与维生素D缺乏 (<90nmol/L) 有关.
- 维持足够的维生素D水平可能对保持COPD患者的肺功能很重要.
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