怀孕期间的西方饮食模式与儿童和青少年的神经发育障碍有关
David Horner1, Jens Richardt M Jepsen2,3, Bo Chawes4
1COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. david.horner@dbac.dk.
Nature metabolism
|March 3, 2025
概括
怀孕期间的西方饮食与儿童的神经发育障碍有关,包括注意力缺陷多动症 (ADHD). 针对孕妇饮食的早期怀孕干预可以帮助预防这些疾病.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 神经发育障碍很普遍,但孕妇饮食在怀孕期间的影响还不够研究.
- 了解产前影响对于儿童神经发育结果至关重要.
研究的目的:
- 研究怀孕期间母亲饮食模式与后代神经发育障碍之间的关联.
- 为了确定潜在的介导代谢物和饮食干预的最佳时间.
主要方法:
- 在COPSAC2010队列中,对怀孕24周的母亲自我报告的饮食模式的分析.
- 在10岁时对神经发育障碍的临床评估.
- 在使用饮食建模,孕产妇和胎儿血液代谢学的独立队列中进行验证.
主要成果:
- 怀孕期间的西方饮食模式与注意力缺陷多动症障碍 (ADHD) 和自闭症诊断有显著联系.
- 代谢分析确定了15种中介代谢物,改善了ADHD的预测.
- 在纵向分析中,在怀孕早期到中期的关联仍然显著.
结论:
- 怀孕期间母亲的西方饮食是儿童神经发育障碍,特别是ADHD的危险因素.
- 产前饮食干预,特别是在怀孕早期,显示出预防神经发育障碍的潜力.
- 代谢学的洞察力可以改进风险预测,并为目标干预提供信息.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
34
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
34
Anorexia Nervosa
41
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
41
Autism Spectrum Disorder
53
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
53
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Disorders of the Nervous Tissue
1.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
1.0K
Bulimia Nervosa
45
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
45


