童年Pb诱导的认知功能障碍:热冷执行功能的结构方程建模
Jamil M Lane1, Shelley H Liu2, Vishal Midya3
1Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. jamil.lane@mssm.edu.
Journal of exposure science & environmental epidemiology
|March 3, 2025
概括
儿童暴露对与情绪和自我调节相关的热执行功能 (EFs) 有负面影响,但对冷EFs没有负面影响. 这些影响在男孩和女孩中都被观察到,这表明的性别没有显著的差异.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展心理学 发展心理学
背景情况:
- 儿童 (Pb) 暴露与前额叶皮层的神经毒性影响有关,影响执行功能 (EFs).
- 有限的研究已经探索了Pb在多个EF维度上的影响,特别是热 (情绪/动机) 和冷 (认知处理) 的EF.
研究的目的:
- 调查儿童Pb暴露对热和冷EF尺寸的影响.
- 评估Pb对EFs的神经毒性影响的潜在基于性别的差异.
主要方法:
- 墨西哥城602名儿童的长度研究,Pb水平测定在4-6岁,EF任务在6-9岁.
- 确认因素分析来定义热和冷EF潜伏变量.
- 结构方程建模 (SEM) 来分析Pb对EF的神经毒性影响,与多组SEM进行基于性别的比较.
主要成果:
- 儿童Pb暴露与男性和女性的热EF表现差显著相关 (p <0.05).
- 在Pb暴露和寒冷EF性能之间没有发现显著的关联 (p = 0.392).
- 对于热或冷EFs,没有观察到性二态效应的证据.
结论:
- 儿童Pb暴露的神经毒性主要影响热EF维度,涉及情绪和自我调节方面.
- 这些发现突出了Pb对认知功能的差异性影响,热EF更容易受到影响.
- 该研究使用了复杂的SEM框架来分析多维认知数据,增加了Pb对EFs影响的新见解.
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