一份关于确定因果关系,治疗应用和在微生物组研究中使用临床前模型的共识声明
Amira Metwaly1,2, Aicha Kriaa3, Zahra Hassani4
1Chair of Nutrition and Immunology, TUM School of Life Sciences, Technical University Munich, Freising, Germany.
Nature reviews. Gastroenterology & hepatology
|March 3, 2025
概括
临床前模型对于了解肠道微生物组在疾病中的作用至关重要. 德尔菲调查确定了选择适当模型研究宿主微生物群相互作用和疾病因果关系的关键考虑因素.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 肠道微生物组显著影响人类健康,影响新陈代谢,免疫力和神经功能.
- 肠道微生物组成的改变与炎症性,代谢性和神经退行性疾病有关.
- 建立肠道微生物组和疾病之间的因果关系是具有挑战性的.
研究的目的:
- 评估临床前模型在研究肠道微生物组在疾病中的因果作用方面的有用性.
- 解决选择适合的模型来研究宿主微生物群相互作用和疾病发病的挑战.
- 为临床前模型选择产生基于共识的建议.
主要方法:
- 人类微生物组行动联盟 (Human Microbiome Action Consortium) 进行了德尔菲调查.
- 方法包括文献综述,专家研讨会和结构化问卷.
- 专家评估了各种临床前模型的优点,局限性和适用性.
主要成果:
- 该调查收集了来自不同利益相关者的关于临床前模型选择的见解.
- 在评估模型有效性的标准上达成共识.
- 确定了研究肠道微生物组与疾病因果关系的关键因素.
结论:
- 临床前模型对于推动我们对肠道微生物群相关疾病的理解至关重要.
- 该研究为优化临床前模型选择提供了有价值的建议.
- 这些见解将指导未来对宿主微生物群相互作用和治疗干预措施的研究.
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