化学起源和真核生物中中央碳代谢的动态演变
Carlos Santana-Molina1, Tom A Williams2, Berend Snel3
1Department of Marine Microbiology and Biogeochemistry, NIOZ, Royal Netherlands Institute for Sea Research, AB Den Burg, the Netherlands.
Nature ecology & evolution
|March 3, 2025
概括
现代真核体新陈代谢保留了其古代共生起源的痕迹. 我们的研究揭示了仿真基因谱,显示了早期的代谢相互作用如何塑造了第一个真核细胞.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 生物化学 生物化学
背景情况:
- 细胞的起源是生命历史上一个关键事件.
- 领先的假设表明,asgardarchaeal宿主和alphaproteobacterial内共生体之间的共生是至关重要的.
- 这些伴侣之间的代谢交叉养被认为有助于他们的整合.
研究的目的:
- 调查现代真核生物代谢是否反映了这种祖先的共生关系.
- 分析参与中央碳代谢的真核基因的进化起源.
主要方法:
- 对真核生物基因库的遗传学分析.
- 对调解中央碳代谢的基因进行序列分析.
- 比较基因组学来追踪祖先的贡献.
主要成果:
- 细胞中枢碳代谢基因是模拟的,起源于阿斯加达古 (糖解) 和阿尔法蛋白细菌 (TCA循环).
- 这种祖先的新陈代谢在超过20亿年前通过基因丢失,转移和重新定位发生了显著的重塑.
- 还确定了来自其他 prokaryotic 源的遗传贡献.
结论:
- 现代真核细胞代谢保存了原始asgardarchaeal-alphaproteobacterial代谢相互作用的证据.
- 这些发现支持合成 (代谢合作) 作为真核细胞起源的关键因素.
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