在慢性便秘中,Lactobacillus gasseri 345A的治疗价值
Stefan Roos1,2, Atti-La Dahlgren3, Yu-Kang Mao4
1Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Neurogastroenterology and motility
|March 3, 2025
概括
乳酸菌可以通过减少腹部疼痛和潜在地提高排便频率来改善功能性便秘. 这种益生菌有望缓解症状并改善便秘患者的肠道功能.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性便秘是一种常见的胃肠道疾病,原因不明.
- 在便秘患者中观察到肠道微生物组合的变化,可能会导致这种情况.
- 益生菌,如Lactobacillus gasseri,正在研究它们对胃肠道疾病的潜在治疗作用.
研究的目的:
- 在临床前模型中研究Lactobacillus gasseri对肠道运动和疼痛的影响.
- 评估Lactobacillus gasseri在改善女性功能性便秘症状方面的疗效.
- 评估Lactobacillus gasseri对肠道排便频率,腹痛和其他相关结果的影响.
主要方法:
- 临床前研究使用小鼠模型来评估Lactobacillus gasseri对肠道运动,阿片类药物诱导的抑制和TRPV1活性的影响.
- 一个随机的,安慰剂控制的临床试验与40名被诊断患有功能性便秘的妇女进行.
- 参与者接受了28天的Lactobacillus gasseri或安慰剂,评估了完全自发性肠道排便 (CSBM),疼痛和其他症状.
主要成果:
- 临床前研究表明,Lactobacillus gasseri增强了肠道运动性,并抵消了阿片类药物诱导的抑制作用.
- 临床试验显示,在接受Lactobacillus gasseri治疗的妇女中,腹部疼痛显著减少.
- 观察到越来越多的CSBM和对肠道排泄功能的积极影响的趋势,副作用最小.
结论:
- 乳杆菌气塞治疗有效地缓解与功能性便秘相关的疼痛.
- 这种益生菌可以改善肠道排空功能,为慢性便秘提供潜在的治疗选择.
- 需要进一步的研究,以充分阐明Lactobacillus gasseri在治疗便秘方面的机制和长期益处.
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