在患有亚临床抑郁症的大学生中,中断了小世界架构和改变了大脑功能网络的默认模式网络拓
Bo Zhang1,2,3, Shuang Liu4,5,6, Sitong Chen1
1Tianjin International Joint Research Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, No.92 Weijin Road, Nankai District, Tianjin, 300072, China.
BMC psychiatry
|March 3, 2025
概括
大学生的亚临床抑郁症 (ScD) 显示了大脑网络拓的改变,小世界架构被破坏,信息传输效率降低. 默认模式网络功能障碍可能会促进抑郁症的发展.
科学领域:
- 神经成像是一种神经成像.
- 大脑网络分析 脑网络分析
- 心理健康 心理健康
背景情况:
- 亚临床抑郁症 (ScD) 是主要抑郁症的前体,在大学生中很普遍.
- 了解SCD大脑网络拓对于理解其神经病理学至关重要.
- 创伤性疾病对医疗服务构成重大负担.
研究的目的:
- 研究患有亚临床抑郁症 (SCD) 个体的大脑网络拓.
- 为了比较SCD和健康对照 (HC) 之间的功能网络特征.
- 为了识别潜在的神经成像标志物SCD.
主要方法:
- 功能磁共振成像 (fMRI) 数据被用来构建功能网络.
- 网络值方法确保了网络的稳定性.
- 图形理论被应用于分析全球和节点拓度量.
主要成果:
- ScD个体表现出颠覆的小世界架构,具有更高的特征路径长度,集群系数和本地效率,但全球效率较低.
- 在默认模式网络 (DMN) 区域和SCD的叶中观察到明显减少的节点中心性.
- 左前结节效率与抑郁症严重程度有负相关性.
结论:
- 在SCD中改变的全球网络指标表明转向正规配置,损害信息传输.
- 由下节点中心性表示的DMN功能障碍是SCD和主要抑郁症的共同神经成像特征.
- DMN 功能障碍可能是导致抑郁症进展的关键因素.
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