在产生用于瘤免疫治疗的CAR-NK细胞方面,CD28优于4-1BB辅助刺激

Pengchao Zhang1,2, Xuejia Feng1, Xiangyun Niu1,2

  • 1Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, People's Republic of China.

概括

CD28辅助刺激增强了化学抗原受体 (CAR) -NK细胞治疗癌症的效果,优于4-1BB设计. MAP3K8激酶被确定为改善CAR-NK细胞抗瘤活性的关键调解剂.