相关实验视频

Updated: May 24, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

肺腺癌中MCM8的表达模式及其与关键生物过程的相关性

Xu-Sheng Liu^1,2,3, Jin Xie⁴, Rui-Min Wu⁵

¹Department of Nuclear Medicine, Hubei Provincial Clinical Research Center for Precision Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. lxsking@taihehospital.com.

European journal of medical research

|March 3, 2025

概括

微染色体维护复杂组件8 (MCM8) 在肺腺癌 (LUAD) 中过度表达,具有作为诊断和预后生物标志物的潜力. 在LUAD中,MCM8水平与生存,免疫透和代谢途径相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

肺腺癌 (LUAD) 由于其高死亡率,对全球健康构成重大挑战.
改进的诊断和预后生物标志物对于改善LUAD患者的治疗结果和治疗策略至关重要.

研究的目的:

在肺腺癌 (LUAD) 中研究微染色体维护复杂组件8 (MCM8) 的表达和临床意义.
评估MCM8作为LUAD潜在的诊断和预后生物标志物.

主要方法:

使用TCGA和GTEx数据集对33种癌症类型的MCM8表达的分析.
使用GEO数据集和免疫组织化学 (IHC) 在LUAD中验证MCM8表达.
诊断准确性的评估 (ROC分析),预后价值 (Kaplan-Meier),免疫透 (CIBERSORT),以及与m6A甲基化,糖解和铁的相关性.

主要成果:

在LUAD和其他癌症中,MCM8显著过度表达.
在MCM8中,LUAD的诊断准确度很高 (AUC = 0.849).
过度表达MCM8与较差的整体和疾病特异性生存,改变的免疫细胞透和与关键癌症相关途径的相关性有关.

结论:

MCM8成为LUAD的有前途的诊断和预后标志物.
需要进一步的研究来阐明MCM8在LUAD发育中的精确机制及其对瘤免疫微环境的影响.

关键词:

铁化是铁化的一种.葡萄糖溶解是什么? 葡萄糖溶解免疫系统的透.肺部腺癌瘤是肺部腺癌.在MCMM8中,MCMM8是MCMM8.m6A 一个很好的.

更多相关视频

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...