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开发和内部验证一个新的预期寿命估计器,用于多病症老年人
Viktoria Gastens1,2,3, Arnaud Chiolero4,5,6, Martin Feller4,7
1Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. viktoria.gastens@unifr.ch.
Diagnostic and prognostic research
|March 3, 2025
概括
研究人员开发了一种新工具,用于估计多种慢性疾病的老年人预期寿命. 这个估计器通过预测复杂患者群体的生存率来帮助个性化护理.
科学领域:
- 老年学是一门学科.
- 临床流行病学临床流行病学
- 生物统计学 生物统计学
背景情况:
- 人口老龄化导致更多的老年人患有多种慢性疾病,需要复杂的护理.
- 目前的临床指南建议基于预期寿命的个性化护理,但对于多病患者的工具缺乏.
研究的目的:
- 开发和内部验证一个预期寿命估计器,专门用于多病症的老年人.
主要方法:
- 来自OPERAM研究的数据分析,包括70岁以上的多病症和多药性参与者.
- 开发一个使用年龄,癌症,药物计数,BMI,体重减轻,住院和功能状态等预测因素的3年死亡率预测指数.
- 内部验证使用启动并将指数转换为通过Gompertz生存函数将指数转换为预期寿命估计器.
主要成果:
- 最终的模型包括年龄,转移性癌症,药物数量,较低的BMI,体重减轻,住院病例和较低的巴特尔指数.
- 该模型显示了中度的歧视 (乐观度调整后的C-统计:0.70) 和良好的校准 (斜率:0.96).
- 预测的平均预期寿命为5.4年;为估计,开发了一个Web应用程序.
结论:
- 成功开发了一种内部验证的多病症老年人预期寿命估计器.
- 在临床实施之前,需要对不同患者群体进行进一步的外部验证.
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