一个受损的面伤口愈合模型用于粒子骨移植的特征:在子中的实体研究
Nourhan Hussein1, Vasudev Vivekanand Nayak2,3, Neeraja Dharmaraj1
1Katz Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas, USA.
概括
这项研究表明,辐射在下缺陷中显著损害骨再生. 照射前临床模型是测试新组织工程疗法用于受损的口腔伤口的宝贵工具.
科学领域:
- 在口腔外科手术中.
- 再生医学是一种再生医学.
- 临床前研究 临床前研究
背景情况:
- 标准的临床前模型经常使用健康的伤床,这些伤床在放射治疗后不能准确地反映受损的口腔环境.
- 放射治疗可以显著影响伤口愈合和骨再生,需要专门的临床前模型.
研究的目的:
- 在一个被辐射的临床前模型中,对关键大小下缺陷的骨再生进行表征.
- 为了评估颗粒物骨移植在受损伤愈合环境中的有效性.
主要方法:
- 在新西兰白中创建了临界大小 (10毫米) 的下缺陷.
- 一组在缺陷创建之前接受了36 Gy辐射 (实验),而对照组没有.
- 两组的缺陷都用牛骨材料 (Bio-Oss) 接种并治愈了8周.
主要成果:
- 组织学分析显示,照射组与对照组相比,照射组的骨形成和桥梁形成较少.
- 照射组显示软组织存在的增加.
- 微计算机断层扫描证实实验组的骨体积显著降低 (22.02% ± 2.71) 与对照组 (27.59% ± 2.71) 相比.
结论:
- 被辐射的子模型显示骨再生能力降低,验证了其用于研究受损伤愈合的用途.
- 该模型适用于对受辐射影响的口腔缺陷的组织工程策略的临床前评估,包括生长因子和3D打印的支架.
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