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胃肠道系统内镜和非透析慢性病的病理发现:单中心研究
Mehmet Usta1, Alparslan Ersoy2, Nazife Nur Özer Şensoy1
1Department of Nephrology, Bursa City Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
概括
透析前慢性病 (CKD) 患者的胃炎和非性病变的发病率较高. 早期内镜评估对于管理这些个体的胃肠道并发症至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理学 病理学 病理学
背景情况:
- 慢性病 (CKD) 与各种胃肠道并发症有关.
- 在CKD患者中,消化不良症状很常见,需要进行调查.
研究的目的:
- 为了比较前透析CKD患者的内镜和病理发现,与呈现消化不良症状的非尿血病患者进行比较.
- 在透析或移植之前,在CKD患者中确定胃肠道病变和Helicobacter pylori (HP) 的流行率.
主要方法:
- 在60名透析前的CKD患者和68名非尿血性对照患者进行了上胃肠道内镜检查.
- 分析了内镜和病理学发现,并在两组之间进行了比较.
- 慢性瘤的定义是血清肌≥1.5 mg/dL和eGFR阶段3a-4 (KDIGO指南).
主要成果:
- 慢性病患者表现出明显更高的腹腔胃炎,红血性胃炎,活性慢性胃炎和非性病变的频率.
- 胃食道逆流频率在各组之间没有显著差异.
- 与对照组 (59.1%) 相比,Helicobacter pylori (HP) 感染在CKD患者 (23.5%) 中明显较低.
结论:
- 尿液中毒素,血液循环受损和高胃血可能导致慢性病患者的胃肠粘膜损伤.
- 胃肠病变的早期内镜检测和管理对于透析前的CKD患者至关重要,特别是移植候选人.
- 内镜评估和治疗可以减轻与免疫抑制疗法相关的风险,并改善结果.
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