基于脂质的营养补充剂对缩儿童肠道标志物的影响:随机试验的二次分析
Hannah Pesu1, Joseph Mbabazi1,2, Rolland Mutumba1,2
1Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Journal of pediatric gastroenterology and nutrition
|March 4, 2025
概括
基于脂质的营养补充剂 (LNS) 在缩儿童中没有改善肠道健康标志物,可能会增加炎症. 它们对巴胺状况的积极影响在肠细胞质量较低的儿童中减少.
科学领域:
- 儿童营养学 儿童营养学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 儿童发育迟缓与肠道健康和营养吸收受损有关.
- 基于脂质的营养补充剂 (LNS) 用于解决营养不良,但它们对肠道完整性的影响需要进一步研究.
研究的目的:
- 为了研究与牛奶蛋白 (MP) 和/或乳清透 (WP) 的LNS对肠道炎症和体质量的影响.
- 确定肠道状况是否影响LNS对生长和微量营养素状况的有效性.
主要方法:
- 一个2x2因子试验随机分配750名乌干达儿童 (12-59个月) 给LNS配方或12周不补充.
- 便髓氧化酶 (f-MPO) 和血素 (p-cit) 被测量为肠道炎症和肠球体质量的标志物.
主要成果:
- LNS没有显著改变f-MPO或p-cit水平.
- 虽然f-MPO在对照组下降,但在LNS组没有变化,这表明LNS的潜在炎症增加.
- 在低肠细胞质量 (p-cit <20 μmol/L) 的儿童中,对可巴拉明 (B12) 状态的LNS疗效降低了.
结论:
- LNS没有改善肠球体质量,可能会使缩儿童的肠道炎症恶化.
- 在儿童中,LNS对巴胺状况的有益影响较少明显,儿童的肠球完整性受到损害.
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