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离子液体杂粘液的微风学,用于有效地输送基于蛋白质的口服药物

Nayanjyoti Kakati¹, Nabendu Paul², Saurabh Dubey³

¹Department of Chemical Engineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.

Small (Weinheim an der Bergstrasse, Germany)

|March 4, 2025

概括

离子液体 (ILs) 通过改善稳定性和粘液透来增强口服蛋白质药物输送. 这项研究揭示了涉及IL-蛋白-肌蛋白系统的分子相互作用,用于先进的药物配方.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
计算化学计算化学

背景情况:

口服蛋白质药物输送面临着由于稳定性不佳和肠粘液透程度有限的挑战.
离子液体 (ILs) 有望提高蛋白质药物稳定性和粘液透性.
调控蛋白质-IL-肌蛋白系统的分子相互作用尚未得到充分理解.

研究的目的:

使用ILs阐明了口服蛋白质药物输送背后的分子机制.
调查模型蛋白药物,ILs和粘蛋白之间的相互作用.
通过模拟的肠粘液来评估蛋白质药物的稳定性和透.

主要方法:

在配方组装过程中跟踪分子相互作用的微观生物学实验.
密度函数理论 (DFT) 模拟以建模分子相互作用.
原子力显微镜 (AFM) 用于形态学研究和扩散波光谱 (DWS) 用于微观学.

主要成果:

微神经学揭示了BSA-mucin-IL复合体形成过程中的关键分子相互作用 (静电,范德瓦尔斯,硬质,键).
形态学和微观学研究证实了ILs对配方稳定性和性能的影响.
一个生物仿真体外原型在ILs的存在下证明了增强的BSA稳定性和粘素透.

结论:

离子液体可以显著提高以蛋白质为基础的口服药物的稳定性和粘液透性.
了解分子相互作用对于设计有效的基于IL的蛋白质药物递送系统至关重要.
这项研究为开发先进的口腔蛋白疗法提供了基础.

关键词:

密度函数理论密度函数理论扩散波谱学是一种波谱学.离子液体是一种离子液体.微流体学在微流体学方面微观神经学微观神经学一个叫做mucincin的孩子.非对应相互作用的非对应相互作用

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