社区获得的Clostridioides difficile感染的流行病学概况:系统性审查和元分析
Neri Alejandro Álvarez-Villalobos1,2,3,4, Fernando Gerardo Ruiz-Hernandez1,2,4, Ana Camila Méndez-Arellano4
1Facultad de Medicina, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 235, Mitras Centro, 64460Monterrey, Nuevo León, México.
社区获得的Clostridioides difficile感染 (CA-CDI) 影响5%的人,每10万人/年有7.3例. 抗生素使用和年龄是这种不断变化的流行病学的关键风险因素.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 艰难菌感染 (CDI) 越来越多地在社区环境中得到认可.
- 关于社区获得的CDI (CA-CDI) 的流行病学数据显示出显著的异质性.
- 了解CA-CDI趋势对于公共卫生战略至关重要.
研究的目的:
- 系统地审查和元分析CA-CDI的流行病学概况.
- 为了确定CA-CDI的综合流行率和发病率.
- 确定与CA-CDI相关的关键风险因素.
主要方法:
- 系统审查和元分析遵循PRISMA和Cochrane指南.
- 在主要数据库 (MEDLINE,Scopus,Web of Science等) 进行全面的文献搜索. 从开始到2023年4月.
- 双项正常模型使用通用线性混合模型进行聚合分析,包括子组分析和出版偏差评估.
主要成果:
- 包括49项关于CA-CDI的观察性研究.
- CA-CDI的综合流行率为5% (95%CI为3-8%).
- 对CA-CDI的综合发病率为每10万人/年7.53 (95%CI为4.45-12.74).
结论:
- 根据目前的文献,CA-CDI的显著流行率为5%,每10万人年发生率为7.3例.
- 以前的抗生素暴露和晚年是CA-CDI的重要风险因素.
- 这一元分析提供了更清晰的CA-CDI的流行病学图片,突出了它的社区负担.
更多相关视频
12:58A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
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