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晨晚生长激素注射及其对睡眠-觉醒模式和白天警觉性的影响
Aglaya Levshtein1, Mohamad Sharkia1, Maya Shimshi-Barash2
1Pediatric Endocrinology and Diabetes Unit, HaEmek Medical Center, Afula, Israel.
Frontiers in endocrinology
|March 4, 2025
概括
无论是早上还是晚上注射生长激素 (GH),都不会影响儿童的睡眠模式或活动水平. 这种灵活性使得家庭可以在最适合他们的时间给予GH疗法.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 生理生长激素 (GH) 的分泌发生在睡眠期间.
- 传统的GH疗法包括每天在睡前注射.
- 晚上GH注射与天然GH分泌模式保持一致,但可能会扰乱睡眠.
研究的目的:
- 为了比较早晨和晚上的每日GH注射对儿童的睡眠和清醒模式,持续时间和活动的影响.
- 评估GH注射时间对儿科患者睡眠参数的影响.
主要方法:
- 一个开放的,随机的交叉试验,涉及20名儿童 (5-14岁) 患有生长激素缺乏或特异性矮身.
- 参与者接受了两周的晚上GH注射,然后两周的早上GH注射 (或反之亦然).
- 在每次治疗期间的第二周,使用7天的动图仪监测睡眠-清醒模式和活动.
主要成果:
- 在早上和晚上GH注射之间没有观察到在床上总时间,总睡眠时间,睡眠效率或睡眠开始延迟方面的显著差异.
- 每晚唤醒的次数和24小时活动指数无论注射时间如何,都保持了可比性.
- 根据诊断 (GH缺乏与特异性矮身) 或性别,没有发现差异.
结论:
- 每天注射生长激素的时间 (早上和晚上) 不会影响儿童的睡眠和清醒模式或活动水平.
- 增生激素注射可以在任何方便的时间进行,为患者和家人提供灵活性.
- 这一发现减轻了人们对晚上GH的潜在睡眠障碍的担忧.
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