细分体构成对中国儿童代谢功能障碍相关的脂肪肝疾病的影响
Meng-Yuan Hu1, Dan-Qin Sun2, Fan Yang3
1Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China.
Frontiers in endocrinology
|March 4, 2025
概括
肢体肌肉比例下降和上肢脂肪增加与儿童代谢功能障碍相关的脂肪肝疾病 (MAFLD) 风险较高有关. 这些身体成分变化表明MAFLD的概率增加.
科学领域:
- 儿科 儿科 儿科
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是儿童群体日益关注的问题.
- 了解身体组成和MAFLD之间的联系对于早期干预至关重要.
研究的目的:
- 调查区域身体组成和中国儿童的MAFLD之间的关联.
- 为了确定与MAFLD相关的特定身体脂肪和肌肉分布模式.
主要方法:
- 评估了1399名7至14岁的儿童.
- 使用Fibroscan (控制衰减参数) 测量肝脏肥胖症.
- MAFLD的诊断被认为是肝脏肥胖症加上超重/肥胖,糖尿病前期/糖尿病或代谢异常.
主要成果:
- 9.57%的儿童被诊断出患有MAFLD.
- 较低的肌肉百分比,特别是在四肢,与MAFLD相反相关 (OR:0.732).
- 更高的区域脂肪百分比,特别是在上肢,与MAFLD正相关 (OR: 3.104).
结论:
- 肢体肌肉减少和上肢脂肪增加与青春期前儿童的MAFLD风险较高有关.
- 这些发现凸显了儿科MAFLD中区域性身体组成的重要性.
- 建议进行进一步的前性研究来验证这些关联.
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