在免疫功能低下和免疫能力强的儿童中,对COVID-19疫苗的免疫记忆
Constanza Russo1, Adrián Otero1, Macarena Uranga2
1Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina.
儿童的COVID-19疫苗免疫力持续长达17个月. 免疫功能低下的儿童对变种的反应较弱,这凸显了这个脆弱群体需要更新的疫苗的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 儿科 儿科 儿科
背景情况:
- 阿根廷大多数儿童完成了最初的COVID-19疫苗系列.
- 在Omicron波之后,人们假定混合免疫力,但免疫力低下 (IC) 儿童的耐用性是未知的.
研究的目的:
- 评估IC和健康儿童 (HC) 免疫记忆的持久性 接种疫苗后1317个月.
- 为了比较针对武汉和Omicron BA.5变种的免疫反应.
主要方法:
- 研究了45名IC和79名HC儿童的队列.
- 评估了血抗尖峰IgG,中和活性以及抗原特异性CD4+和CD8+T细胞.
主要成果:
- 与HC相比,IC儿童对武汉和Omicron BA.5的中和标位较低,特别是在两剂BBIBP-CorV或BNT162b2.2.后.
- 即使在三次剂量后,IC儿童也表现出较弱的中和抗体和CD8+T细胞反应,IFN-γ的产生减少.
- 分析显示IC儿童的免疫记忆力较弱,特别是CD8+ T细胞反应受损.
结论:
- 针对COVID-19的免疫记忆可以持续至少17个月.
- 疫苗对新变种的有效性降低,需要为IC儿童提供更新的疫苗.
- 加强疫苗接种策略至关重要,以保护这个脆弱的儿科群体.
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